ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13226ometendo-13226Research ArticleОБЗОРREVIEW«Обесогенная память» как нейробиологический механизм, предопределяющий рецидивирующее течение ожирения«Obesogenic memory» as a neurobiological mechanism predicting the recurrent course of obesityhttps://orcid.org/0000-0002-5057-127XШестаковаМ. В.ShestakovaM. V.

Шестакова Марина Владимировна, д.м.н., профессор, академик РАН

Москва

Researcher ID: D-9123-2012

Scopus Author ID: 7004195530

Christina E. Zakharova, resident

11 Dmitry Ulyanov street, 117292 Moscow

shestakova.mv@gmail.comhttps://orcid.org/0009-0000-6025-7885ЗахароваК. Э.ZakharovaK. E.

Захарова Кристина Эдуардовна

г. Москва, ул. Дмитрия Ульянова, д. 11, индекс 117292

Marina V. Shestakova, MD, PhD, Professor

Moscow

Researcher ID: D-9123-2012

Scopus Author ID: 7004195530

christinzakharova@gmail.comhttps://orcid.org/0009-0006-4269-4348ЮрченковаИ. М.YurchenkovaI. M.

Юрченкова Инна Максимовна

Москва

Inna M. Yurchenkova, resident

Moscow

yurchenkova.inna@mail.ruГНЦ РФ ФГБУ «НМИЦ эндокринологии им. академика И.И. Дедова» Минздрава РоссииРоссияEndocrinology research centreRussian Federation202514022026224366373Copyright © Шестакова М.В., Захарова К.Э., Юрченкова И.М., 20262026Шестакова М.В., Захарова К.Э., Юрченкова И.М.Shestakova M.V., Zakharova K.E., Yurchenkova I.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13226

Ожирение является значимой проблемой здравоохранения во всем мире. Оно связано с множеством сопутствующих заболеваний и значительно снижает качество жизни. Успехи в изучении патогенеза метаболических нарушений способствуют разработке и внедрению в клиническую практику инновационных технологий для борьбы с эпидемией ожирения. Однако до сих пор механизмы, вовлеченные в возврат веса, остаются недостаточно исследованными. Поддержание массы тела регулируется взаимодействием множества физиологических процессов. Целью данного литературного обзора является анализ существующих исследований «обесогенной памяти» как нейробиологического механизма, предопределяющего рецидивирующее течение ожирения.

Obesity is a significant healthcare problem worldwide. It is associated with a multitude of comorbidities and significantly reduces the quality of life. Success in the study of the pathogenesis of metabolic disorders contribute to development and introduction of innovative technologies into the clinical practice to combat the epidemic of obesity. However, so far the mechanisms involved in weight regain remain not fully understood. Maintaining body weight is regulated by the interaction of many physiological processes. The purpose of this review is to analyze existing studies dedicated to the biological mechanisms leading weight regain after successful treatment of obesity.

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The authors declare that there are no conflicts of interest present.