ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13217ometendo-13217Research ArticleОБЗОРЫREVIEWSОсобенности метаболизма витамина D при беременностиFeatures of vitamin D metabolism during pregnancyhttps://orcid.org/0000-0002-4388-6097КацобашвилиИ. А.KatsobashviliI. A.

Кацобашвили Илана Александровна

117292, Москва, ул. Дм. Ульянова, д. 11

Ilana A. Katsobashvili - MD

11 Dm. Ulyanova street, 117292 Moscow

kacobashvili.ilana@mail.ruhttps://orcid.org/0000-0001-6539-466XПигароваЕ. А.PigarovaE. A.

Пигарова Екатерина Александровна - д.м.н.; Scopus Author ID: 55655098500; Researcher ID: T-9424-2018.

Москва

Ekaterina A. Pigarova - MD, PhD. Scopus Author ID: 55655098500; Researcher ID: T-9424-2018.

Moscow

kpigarova@gmail.comhttps://orcid.org/0000-0001-7470-1676ВоротниковаС. Ю.VorotnikovaS. Y.

Воротникова Светлана Юрьевна - к.м.н.

Москва

Svetlana Y.Vorotnikova - MD, PhD.

Moscow

bra_svetix@list.ruhttps://orcid.org/0000-0001-5952-5846БибикЕ. Е.BibikE. E.

Бибик Екатерина Евгеньевна - к.м.н; Researcher ID: AAY-3052-2020; Scopus Author ID: 57195679482

Москва

Ekaterina E. Bibik - MD, PhD; Researcher ID: AAY-3052-2020; Scopus Author ID: 57195679482.

Moscow

bibikaterina@mail.ruhttps://orcid.org/0000-0002-0327-4619ДзерановаЛ. К.DzeranovaL. K.

Дзеранова Лариса Константиновна - д.м.н.

Москва

Larisa K. Dzeranova - MD, PhD.

Moscow

dzeranovalk@yandex.ruФГБУ «НМИЦ эндокринологии им. академика И.И. Дедова» Минздрава РоссииРоссияI.I. Dedov National Medical Research Center of EndocrinologyRussian Federation202503092025222111117Copyright © Кацобашвили И.А., Пигарова Е.А., Воротникова С.Ю., Бибик Е.Е., Дзеранова Л.К., 20252025Кацобашвили И.А., Пигарова Е.А., Воротникова С.Ю., Бибик Е.Е., Дзеранова Л.К.Katsobashvili I.A., Pigarova E.A., Vorotnikova S.Y., Bibik E.E., Dzeranova L.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13217

Витамин D играет важную роль в регуляции системы «мать-плацента-плод», участвуя в обеспечении нормального роста и развития плода, снижая риски гипокальциемии, мышечных судорог, инфекций дыхательных путей в детском возрасте. К настоящему времени установлено существование более 50 метаболитов витамина D, из которых наиболее изученными являются общий 25-гидроксивитамин D (25(ОН)D) и 1,25-дигидроксивитамин D (1,25(ОН)2D), что обус­ловлено, прежде всего, их важностью для эндокринной регуляции кальций-фосфорного обмена. Уровень 25(OH)D в крови представляет собой оптимальный, но не совершенный маркер обеспеченности витамином D, не отражает многочисленные эффекты его метаболитов. С учетом особой метаболической адаптации организма женщины в период гестации, анализ количественных изменений различных метаболитов витамина D представляет особую актуальность. В настоящем обзоре обобщены имеющиеся данные об особенностях метаболизма витамина D вне гестации и при беременности.

Vitamin D plays an important role in the regulation of the «mother-placenta-fetus» system, participating in ensuring normal growth and development of the fetus, reducing the risks of hypocalcemia, muscle cramps, respiratory infections in childhood. To date, the existence of more than 50 metabolites of vitamin D has been established, of which the most studied are total 25-hydroxyvitamin D (25 (OH) D) and 1,25-dihydroxyvitamin D (1,25 (OH) 2D), which is due, first of all, to their importance for the endocrine regulation of calcium-phosphorus metabolism. The level of 25 (OH) D in the blood is an optimal, but not perfect marker of vitamin D status, and does not reflect the numerous effects of its metabolites. Taking into account the special metabolic adaptation of a woman’s body during gestation, the analysis of quantitative changes in various vitamin D metabolites is of particular relevance. This review summarizes the available data on the characteristics of vitamin D metabolism outside gestation and during pregnancy.

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The authors declare that there are no conflicts of interest present.