ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13195ometendo-13195Research ArticleКЛИНИЧЕСКИЙ СЛУЧАЙCASE REPORTРедкий случай сочетания у одной пациентки метаболических и генетических изменений (синдрома множественных эндокринных неоплазий 1 типа и синдрома Вильямса)A rare case of a combination of metabolic and genetic changes in one patient (multiple endocrine neoplasia type 1 syndrome and Williams syndrome)https://orcid.org/0009-0006-4490-8880ФилькинаЕ. Е.FilkinaE. E.

Филькина Екатерина Евгеньевна

117292, Москва, улица Дм. Ульянова, д. 11

Ekaterina E. Filkina

11 Dm. Ulyanova street, 117292 Moscow

katia.v.e@mail.ruhttps://orcid.org/0000-0001-9119-2447ПржиялковскаяЕ. Г.PrzhiyalkovskayaE. G.

Пржиялковская Елена Георгиевна, к.м.н.

117292, Москва, улица Дм. Ульянова, д. 11

Elena G. Przhiyalkovskaya, MD, PhD

11 Dm. Ulyanova street, 117292 Moscow

przhiyalkovskaya.elena@gmail.comhttps://orcid.org/0000-0002-1974-7564ЛазареваА. А.LazarevaA. A.

Лазарева Анна Александровна

117292, Москва, улица Дм. Ульянова, д. 11

Anna A. Lazareva, MD

11 Dm. Ulyanova street, 117292 Moscow

Lazareva.Anna@endocrincentr.ruhttps://orcid.org/0000-0002-8771-8300ЮкинаМ. Ю.YukinaM. Yu.

Юкина Марина Юрьевна, к.м.н.

117292, Москва, улица Дм. Ульянова, д. 11

Researcher ID: P-5181-2015

 

Scopus Author ID: 57109367700

Marina Yu. Yukina, MD, PhD

11 Dm. Ulyanova street, 117292 Moscow

Researcher ID: P-5181-2015

 

Scopus Author ID: 57109367700

yukina.marina@endocrincentr.ruГНЦ РФ ФГБУ «Национальный медицинский исследовательский центр эндокринологии»РоссияEndocrinology Research CentreRussian Federation202428102024214425430Copyright © Филькина Е.Е., Пржиялковская Е.Г., Лазарева А.А., Юкина М.Ю., 20252025Филькина Е.Е., Пржиялковская Е.Г., Лазарева А.А., Юкина М.Ю.Filkina E.E., Przhiyalkovskaya E.G., Lazareva A.A., Yukina M.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13195

Синдром Вильямса является редким генетическим заболеванием, возникающим в результате микроделеции хромосомной области 7q11.23, предположительно, с аутосомно-доминантным типом наследования. Синдром множественных эндокринных неоплазий 1 типа (МЭН-1) является наследственной патологией, возникающей в связи с аутосомно-доминантным дефектом в гене-супрессоре опухолей MEN1, который расположен на хромосоме 11q13. На сегодняшний день распространенность синдрома Вильямса составляет 1 случай на 7500 новорожденных, а МЭН-1 — 3–20 случаев на 100 000 населения. Сочетание двух генетических синдромов у одного пациента — достаточно редкая ситуация. В статье представлено описание клинического случая сочетания синдрома Вильямса и синдрома МЭН-1 у одной пациентки, что, учитывая низкую частоту встречаемости обоих заболеваний, представляет научный интерес. В работе обсуждаются трудности своевременной диагностики редкого сочетания синдромов, патофизиологические механизмы сочетанного воздействия данных синдромов на сердечно-сосудистую систему, а также последствия неоправданно отложенного кардиохирургического лечения, которые привели к декомпенсации сердечной недостаточности

Asthma and obesity are diseases characterized by variability in the course and possible complications, the frequency of which is steadily increasing from year to year. The correlation between obesity and asthma is still an acute problem of the health care system. Representing very common diseases, they aggravate each other’s course and significantly worsen the quality of life. Polyphenols are a promising option to solve the existing problem. These low molecular weight compounds are biologically active substances capable of influencing on many metabolic processes in the body. This review demonstrates the multiple properties of these unique micronutrients, including antioxidant, anti-carcinogenic, anti-inflammatory, metabolic, neuroprotective and many others. The integration of polyphenols into the daily diet can contribute to strengthening public health, reducing the frequency and progression of socially significant diseases, and using these compounds in diseases such as asthma and obesity, according to numerous modern studies, it is possible to achieve a significant therapeutic effect at all. The purpose of this literature review is to trace the correlation between the effect of using polyphenols and changes in the course of the disease and quality of life in patients with asthma on the background of obesity, based on facts from advanced sources

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The authors declare that there are no conflicts of interest present.