ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13182ometendo-13182Research ArticleКЛИНИЧЕСКИЙ СЛУЧАЙCASE REPORTМорбидное ожирение у пациента с акромегалией: клинический случайObesity in a patient with acromegaly: a case reporthttps://orcid.org/0009-0007-6576-3876ГабаидзеГ. Д.GabaidzeG. D.

Габаидзе Георгий Джемалович.

117292, Москва, улица Дм. Ульянова, д. 11

Georgy D. Gabaidze.

11 Dm. Ulyanova street, 117292 Moscow

mrkingdom444@gmail.comhttps://orcid.org/0000-0001-5824-6490ПерепеловаМ. А.PerepelovaM. A.

Перепелова Маргарита Александровна.

Москва

Margarita A. Perepelova - MD.

Moscow

Perepelova.Margarita@endocrincentr.ruhttps://orcid.org/0000-0001-9119-2447ПржиялковскаяЕ. Г.PrzhiyalkovskayaE. G.

Пржиялковская Елена Георгиевна - к.м.н.

Москва

Elena G. Przhiyalkovskaya - MD, PhD.

Moscow

przhiyalkovskaya.elena@gmail.comhttps://orcid.org/0000-0001-6539-466XПигароваЕ. А.PigarovaE. A.

Пигарова Екатерина Александровна - д.м.н.

Москва

Ekaterina A. Pigarova - MD, PhD.

Moscow

kpigarova@gmail.comhttps://orcid.org/0000-0003-1387-8536КузьминА. Г.KuzminA. G.

Кузьмин Анатолий Геннадьевич - к.м.н.

Москва

Anatoly G. Kuzmin - MD, PhD.

Moscow

kuzmin.anatoliy@endocrincentr.ruhttps://orcid.org/0000-0003-3370-8630ВенгржиновскаяО. И.VengrzhinovskayaO. I.

Венгржиновская Оксана Игоревна.

Москва

Oksana I. Vengrzhinovskaya - MD.

Moscow

vengrzhinovskay@gmail.comhttps://orcid.org/0000-0003-4353-6705ЛапшинаА. М.LapshinaA. M.

Лапшина Анастасия Михайловна - к.м.н.

Москва

Anastasia M. Lapshina - forensic pathologist, PhD.

Moscow

anastasya.lapshina@endocrincentr.ruhttps://orcid.org/0000-0002-0327-4619ДзерановаЛ. К.DzeranovaL. K.

Дзеранова Лариса Константиновна - д.м.н.

Москва

Larisa K. Dzeranova - MD, PhD.

Moscow

dzeranovalk@yandex.ruГНЦ РФ ФГБУ «НМИЦ эндокринологии» Минздрава РоссииРоссияEndocrinology research centreRussian Federation202427092024213331338Copyright © Габаидзе Г.Д., Перепелова М.А., Пржиялковская Е.Г., Пигарова Е.А., Кузьмин А.Г., Венгржиновская О.И., Лапшина А.М., Дзеранова Л.К., 20242024Габаидзе Г.Д., Перепелова М.А., Пржиялковская Е.Г., Пигарова Е.А., Кузьмин А.Г., Венгржиновская О.И., Лапшина А.М., Дзеранова Л.К.Gabaidze G.D., Perepelova M.A., Przhiyalkovskaya E.G., Pigarova E.A., Kuzmin A.G., Vengrzhinovskaya O.I., Lapshina A.M., Dzeranova L.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13182

Акромегалия — тяжелое нейроэндокринное заболевание, характеризующееся гиперпродукцией соматотропного гормона (СТГ). Медленно прогрессирующая симптоматика увеличивает сроки диагностического поиска вплоть до 15 лет. Постоянное воздействие избытка СТГ на организм человека может вызывать структурные и функциональные нарушения органов. К основным осложнениям акромегалии относятся поражения сердечно-сосудистой, дыхательной, опорно-двигательной систем, а также нарушение углеводного обмена и повышенный риск развития неоплазий.

Зачастую неспецифические симптомы акромегалии могут маскироваться под другие патологии или их осложнения, такие как ожирение. Увеличение подкожно-жировой клетчатки, повышение артериального давления, боли в суставах, отеки, нарушение углеводного, липидного обменов наблюдаются как при акромегалии, так и при ожирении. При этом дополнительным фактором возникновения ожирения как осложнения акромегалии является развитие апноэ сна, запускающее череду патологических процессов, в итоге приводящих к синдрому Пиквика.

Нами представлен клинический случай пациента с акромегалией и морбидным ожирением, обсуждаются особенности влияния повышенной массы тела на течение основного заболевания, наличия осложнений и индивидуальный подход в лечении.

Acromegaly is a severe neuroendocrine disease characterized by excessive production of the growth hormone (GH). The slow development of symptoms increases the diagnostic search up to 15 years. Permanent effect of the growth hormone on the human body can cause structural and functional disorders of organs. The main complications of acromegaly include cardiovascular, respiratory, and musculoskeletal system dysfunction, as well as impaired carbohydrate metabolism and an increased risk of developing neoplasms.

Often, nonspecific symptoms of acromegaly can be masked by other pathologies or their complications, such as obesity. An increase in subcutaneous fat, increased blood pressure, joint pain, edema, and impaired carbohydrate and lipid metabolism are observed both in acromegaly and in obesity. An additional factor in the development of obesity as a complication of acromegaly is the development of sleep apnea, which triggers a series of pathological processes that ultimately lead to Pickwickian syndrome.

We present a clinical case of a patient with acromegaly and obesity, discussing the effects of excess body weight on the course of the underlying disease, the presence of complications, and an individual approach to treatment.

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The authors declare that there are no conflicts of interest present.