ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13161ometendo-13161Research ArticleОБЗОРЫREVIEWSОжирение, сахарный диабет и витамин DObesity, diabetes and vitamin Dhttps://orcid.org/0000-0001-6539-466XПигароваЕ. А.PigarovaE. A.

Пигарова Екатерина Александровна - д.м.н., вед. научн. сотрудник отделения нейроэндокринологии, директор Института высшего и дополнительного профессионального образования.

117036, Москва, ул. Дмитрия Ульянова, д. 11

Scopus Author ID 55655098500; ResearcherId T-9424-2018

Ekaterina A. Pigarova - MD, PhD, senior researcher at the Neuroendocrinology and osteopathies Department.

11 Dm. Ulyanova street, 117036 Moscow

Scopus Author ID 55655098500; ResearcherId T-9424-2018

kpigarova@gmail.comhttps://orcid.org/0000-0002-0327-4619ДзерановаЛ. К.DzeranovaL. K.

Дзеранова Лариса Константиновна - д.м.н.

117036, Москва, ул. Дмитрия Ульянова, д. 11

Larisa K. Dzeranova - MD, PhD.

11 Dm. Ulyanova street, 117036 Moscow

dzeranovalk@yandex.ruФГБУ «НМИЦ эндокринологии» Минздрава РоссииРоссияEndocrinology Research CentreRussian Federation202426092024213316324Copyright © Пигарова Е.А., Дзеранова Л.К., 20242024Пигарова Е.А., Дзеранова Л.К.Pigarova E.A., Dzeranova L.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13161

Дефицит и недостаточность витамина D широко распространены в глобальном масштабе, при этом в их развитии играют роль многочисленные факторы, такие как ограниченное воздействие солнечного света, недостаточное питание, заболевания ЖКТ, а также ожирение, которое затрагивает примерно 39% взрослого населения мира. Помимо своей канонической роли в функционировании скелета, витамин D модулирует адипогенез, а также секрецию и действие инсулина при диабете. Недостаточность витамина D, обусловленная ожирением, вероятно, связана со снижением биодоступности витамина D посредством синтеза в коже и из пищевых источников, что связано с его отложениями в жировых депо организма, тогда как прямое действие на адипогенез, по-видимому, реализуется в критические периоды жизни (пре- и постнатальные периоды). Витамин D напрямую регулирует гены, участвующие в путях секреции и действии инсулина. Широкая мировая распространенность дефицита витамина D может быть связана с высокой заболеваемостью СД 2 типа (СД2), а нормализация уровня витамина D у пациентов может быть эффективной стратегией по замедлению прогрессирования СД2 и его осложнений.

Vitamin D deficiency and insufficiency are widespread globally with multiple factors playing a role in their development. Such as limited exposure to sunlight, poor nutrition, gastrointestinal diseases, and obesity, which affects approximately 39% of the world’s adult population. In addition to its canonical role in skeletal function, vitamin D modulates adipogenesis, insulin secretion, and action in diabetes. Vitamin D deficiency due to obesity is likely due to decreased bioavailability of vitamin D through synthesis in the skin and from dietary sources, which is associated with its deposition in body fat depots. While a direct effect on adipogenesis appears to be realized during critical periods of life (pre- and postnatal periods). Vitamin D directly regulates genes involved pathways of insulin secretion and action. The high worldwide prevalence of vitamin D deficiency may be associated with the high incidence of type 2 diabetes, and normalizing vitamin D levels in patients may be an effective strategy to slow the progression of type 2 diabetes and its complications.

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The authors declare that there are no conflicts of interest present.