ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13133ometendo-13133Research ArticleОБЗОРЫREVIEWSПоражение суставов у пациентов с акромегалией: потенциальные маркеры ранней диагностикиJoint involvement in patients with acromegaly: potential markers for early diagnosishttps://orcid.org/0000-0001-5824-6490ПерепеловаМ. А.PerepelovaM. A.

Перепелова Маргарита Александровна 

117292, ул. Дмитрия Ульянова, д. 11 

Margarita A. Perepelova 

11 Dm. Ulyanova street, 117292 Moscow

margo.doktor@mail.ruhttps://orcid.org/0000-0002-9314-7831ЛуценкоА. С.LutsenkoA. S.

Луценко Александр Сергеевич, к.м.н. 

Москва

Alexander S. Lutsenko, MD, PhD

Moscow

some91@mail.ruhttps://orcid.org/0000-0001-8144-4188УткинаМ. B.UtkinaM. V.

Уткина Марина Валерьевна, к.б.н. 

Москва

Marina V. Utkina, PhD in biology

Moscow

mv.utkina@yandex.ruhttps://orcid.org/0000-0001-7965-9454ТарбаеваН. В.TarbaevaN. V.

Тарбаева Наталья Викторовна, к.м.н. 

Москва

Natalya V. Tarbaeva, MD, PhD

Moscow

ntarbaeva@inbox.ruhttps://orcid.org/0000-0001-9119-2447ПржиялковскаяЕ. Г.PrzhiyalkovskayaE. G.

Пржиялковская Елена Георгиевна, к.м.н. 

Москва

Elena G. Przhiyalkovskaya, MD, PhD

Moscow

przhiyalkovskaya.elena@gmail.comНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian Federation202417062024212195204Copyright © Перепелова М.А., Луценко А.С., Уткина М.B., Тарбаева Н.В., Пржиялковская Е.Г., 20242024Перепелова М.А., Луценко А.С., Уткина М.B., Тарбаева Н.В., Пржиялковская Е.Г.Perepelova M.A., Lutsenko A.S., Utkina M.V., Tarbaeva N.V., Przhiyalkovskaya E.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13133

Акромегалия — орфанное нейроэндокринное заболевание, обусловленное повышенной продукцией гормона роста (ГР) и инсулиноподобного фактора роста — 1 (ИФР-1), которое вызывает поражение суставов, являясь пусковым механизмом для разрушения хрящевой ткани.

У пациентов с акромегалией, особенно в активной стадии, превалируют жалобы на боль в суставах различной локализации. Боль в суставах может быть одним из первых симптомов нейроэндокринного заболевания, интенсивность которой прогрессирует при отсутствии необходимого лечения. Повышенная продукция ГР вызывает изменение конфигурации сустава, что, в свою очередь, запускает деструктивные процессы, характерные для дегенеративных заболеваний, таких как остеоартрит (ОА). Несмотря на успешное лечение акромегалии, проблемы, связанные с поражением суставов, могут сохраняться и значительно ухудшать качество жизни пациентов. В связи с этим актуален поиск потенциальных маркеров раннего поражения суставов при акромегалии для применения в прогнозировании тяжести течения артропатии и динамического наблюдения данной когорты пациентов.

В обзоре представлена общая характеристика влияния ГР на хрящевую ткань, особенности патологии опорно-двигательного аппарата у пациентов с акромегалией и потенциальные маркеры, ассоциированные с ранним поражением суставов.

Acromegaly is a rare neuroendocrine disease caused by excessive production of growth hormone (GH), which acts as a trigger for cartilage tissue destruction leading to joint damage.

Patients with acromegaly, especially in the active stage, often complain of joint pain in various locations. Joint pain can be one of the first symptoms of the disease, the intensity of which worsens without proper treatment. Increased production of GH leads to configuration changes in the joints, which in turn trigger destructive processes typical of degenerative diseases such as osteoarthritis. Despite successful treatment of acromegaly, joint-related issues can persist and significantly worsen the quality of life for patients. In this regard, the search for potential markers of early joint involvement in acromegaly is relevant for use in predicting the severity of arthropathy progression and monitoring this cohort of patients.

This review provides a general overview of the effects of growth hormone on cartilage tissue, the characteristics of musculoskeletal pathology in patients with acromegaly and possible markers associated with early joint damage.

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The authors declare that there are no conflicts of interest present.