ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13103ometendo-13103Research ArticleКЛИНИЧЕСКИЙ СЛУЧАЙCASE REPORTКлинический случай бессимптомной соматотропиномы у пациентки с морбидным ожирениемClinical case of somatotropinoma in a patient with morbid obesityhttps://orcid.org/0000-0002-8694-2474ГусейноваР. М.GuseinovaR. M.

Гусейнова Раисат Магомедкамиловна

117036, Москва, ул. Дм. Ульянова, д. 11

Scopus Author ID: 58077013800

Researcher ID: HDO-1221-2022

Raisat M. Guseinova, MD

11 Dm. Ulyanova street, 117036 Moscow

Scopus Author ID: 58077013800

Researcher ID: HDO-1221-2022

rasgus-9@mail.ruhttps://orcid.org/0000-0001-6294-7601АверкинаА. А.AverkinaA. A.

Аверкина Анастасия Алексеевна 

Москва

Anastasia A. Averkina, MD

Moscow

averkinaanastasia.a@gmail.comhttps://orcid.org/0009-0002-1988-4590РафаелянМ. Г.RafaelyanM. G.

Рафаелян Манушак Гагиковна

Москва

Rafaelyan Manushak Gagikovna, MD

Moscow

dr.rfln@bk.ruhttps://orcid.org/0000-0002-9299-1053ВасюковаО. В.VasyukovaO. V.

Васюкова Ольга Владимировна, к.м.н.

Москва

Researcher ID: AAO-375 0-2020

Scopus Author ID: 57192194141

Olga V. Vasyukova, MD, PhD

Moscow

Researcher ID: AAO-375 0-2020

Scopus Author ID: 57192194141

Vasukova.Olga@endocrincentr.ruhttps://orcid.org/0000-0001-8425-0020АндрееваЕ. Н.AndreevaE. N.

Андреева Елена Николаевна, д.м.н., профессор

Москва

Elena N. Andreeva, MD, PhD, professor

Moscow

endogin@mail.ruПигароваЕ. А.PigarovaE. A.

Пигарова Екатерина Александровна, д.м.н. 

Москва

Scopus Author ID: 55655098500

Researcher ID: T-9424-2018

Ekaterina A. Pigarova, MD, PhD

Moscow

Scopus Author ID: 55655098500

Researcher ID: T-9424-2018

kpigarova@gmail.comhttps://orcid.org/0000-0001-9718-6099АзизянВ. Н.AzizyanV. N.

Азизян Вилен Неронович, к.м.н., нейрохирург

Москва

Vilen N. Azizyan, PhD, MD, neurosurgeon

Moscow

vazizyan@mail.ruhttps://orcid.org/0000-0003-2122-2297БондаренкоЕ. В.BondarenkoE. V.

Бондаренко Екатерина Владимировна, к.м.н.

Москва

Ekaterina V. Bondarenko, MD, PhD

Moscow

ekaterinabondarenko@inbox.ruhttps://orcid.org/0009-0000-2932-0399КопытинаД. А.KopytinaD. A.

Копытина Дарья Александровна

117036, Москва, ул. Дм. Ульянова, д. 11

Scopus Author ID: 58853779500

Daria A. Kopytina, MD

Moscow

Scopus Author ID: 58853779500

Kopytina.Daria@endocrincentr.ruhttps://orcid.org/0000-0001-5724-6763ДоровскихА. В.DorovskikhA. V.

Доровских Анна Владимировна

Москва

Anna V. Dorovskikh, MD

Moscow

a.v.dorovskikh@gmail.comhttps://orcid.org/0000-0002-9717-9742МокрышеваН. Г.MokryshevaN. G.

Мокрышева Наталья Георгиевна, д.м.н., профессор, член-корр. РАН

Москва

Natalia G. Mokrysheva, MD, PhD, Professor

Moscow

mokrisheva.natalia@endocrincentr.ruНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian Federation2025240520252215259Copyright © Гусейнова Р.М., Аверкина А.А., Рафаелян М.Г., Васюкова О.В., Андреева Е.Н., Пигарова Е.А., Азизян В.Н., Бондаренко Е.В., Копытина Д.А., Доровских А.В., Мокрышева Н.Г., 20252025Гусейнова Р.М., Аверкина А.А., Рафаелян М.Г., Васюкова О.В., Андреева Е.Н., Пигарова Е.А., Азизян В.Н., Бондаренко Е.В., Копытина Д.А., Доровских А.В., Мокрышева Н.Г.Guseinova R.M., Averkina A.A., Rafaelyan M.G., Vasyukova O.V., Andreeva E.N., Pigarova E.A., Azizyan V.N., Bondarenko E.V., Kopytina D.A., Dorovskikh A.V., Mokrysheva N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13103

Ожирение — это хроническое, эндокринное заболевание, обусловленное избыточным содержанием жировой ткани и ассоциированное с развитием ряда неблагоприятных метаболических процессов в организме.

В работе демонстрируется случай из практики, включающий выявление у пациентки гормонально-активной микроаденомы гипофиза на фоне морбидного ожирения и репродуктивной дисфункции. Применение описанного мультидисциплинарного подхода привело к своевременной верификации основного заболевания и маршрутизации пациентки в специализированный центр, позволило предотвратить развитие осложнений, ассоциированных с наличием акромегалии, и улучшить качество жизни. Восстановление циклической овариальной функции после нейрохирургического вмешательства на фоне регресса жировой массы привели к клиническому улучшению самочувствия и наступлению беременности. В настоящее время пациентка находится под наблюдением многопрофильной команды специалистов.

Obesity is a chronic endocrine disorder characterized by excessive adipose tissue and associated with development of various adverse metabolic processes in the body.

This case report highlights a clinical case involving the detection of a hormonally active pituitary microadenoma in a patient with morbid obesity and reproductive dysfunction. The application of a described multidisciplinary approach led to the timely verification of the underlying condition and the routing of the patient to a specialized center, which prevented the development of complications associated with acromegaly and improved the patient’s quality of life. Restoration of cyclic ovarian function following neurosurgical intervention and regression of adipose mass resulted in clinical improvement of well-being and the occurrence of pregnancy. Currently, the patient is under the care and observation of a multidisciplinary team of specialists.

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Pregnancy in a woman with acromegaly after transsphenoidal partial resection of pituitary macroadenoma - a case report. Pol Merkur Lekarski. 2017;43(258):268-271Fielder S, Nickkho-Amiry M, Seif MW. Obesity and menstrual disorders. Best Pract Res Clin Obstet Gynaecol. 2023;89:102343. doi:10.1016/j.bpobgyn.2023.102343Caron P, Broussaud S, Bertherat J, et al. Acromegaly and pregnancy: a retrospective multicenter study of 59 pregnancies in 46 women. J Clin Endocrinol Metab. 2010;95(10):4680-4687. doi: https://doi.org/10.1210/jc.2009-2331Pirchio R, Auriemma RS, Grasso LFS, et al. Fertility in Acromegaly: A Single-Center Experience of Female Patients During Active Disease and After Disease Remission. J Clin Endocrinol Metab. 2023;108(8):e583-e593. doi:10.1210/clinem/dgad042Pirchio R, Auriemma RS, Grasso LFS, et al. Fertility in Acromegaly: A Single-Center Experience of Female Patients During Active Disease and After Disease Remission. J Clin Endocrinol Metab. 2023;108(8):e583-e593. doi:10.1210/clinem/dgad042Tomczyk K, Rzymski P, Woźniak J, Wilczak M. Pregnancy in a woman with acromegaly after transsphenoidal partial resection of pituitary macroadenoma - a case report. Pol Merkur Lekarski. 2017;43(258):268-271.Tomczyk K, Rzymski P, Woźniak J, Wilczak M. Pregnancy in a woman with acromegaly after transsphenoidal partial resection of pituitary macroadenoma - a case report. Pol Merkur Lekarski. 2017;43(258):268-271.Caron P, Broussaud S, Bertherat J, et al. Acromegaly and pregnancy: a retrospective multicenter study of 59 pregnancies in 46 women. J Clin Endocrinol Metab. 2010;95(10):4680-4687. doi:10.1210/jc.2009-2331Caron P, Broussaud S, Bertherat J, et al. Acromegaly and pregnancy: a retrospective multicenter study of 59 pregnancies in 46 women. J Clin Endocrinol Metab. 2010;95(10):4680-4687. doi:10.1210/jc.2009-2331

The authors declare that there are no conflicts of interest present.