ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13070ometendo-13070Research ArticleОБЗОРЫREVIEWSВлияние пищевых молекул на переход белой жировой ткани в бежевуюNutrient molecules affecting the white-to-beige adipose tissue transitionhttps://orcid.org/0000-0003-1666-8147ЕгороваВ. С.EgorovaV. S.

Егорова Вера Сергеевна - к.б.н., научный сотрудник [

Сириус

Researcher ID IWD-9182-2023; Scopus Author ID 57195327345

Vera S. Egorova - PhD, Researcher.

Sirius

Researcher ID IWD-9182-2023; Scopus Author ID 57195327345

egorova.vs@talantiuspeh.ruГурциеваД. Т.GurtsievaD. T.

Гурциева Дзерасса Таймуразовна - аспирант, младший научный сотрудник.

Сириус

Researcher ID KSL-9382-2024; Scopus Author ID 58848190600

Dzerassa T. Gutrsieva - PhD student, Junior researcher.

Sirius

Researcher ID KSL-9382-2024; Scopus Author ID 58848190600

gurtsieva.dt@talantiuspeh.ruhttps://orcid.org/0000-0002-5953-8097ЕгоровА. Д.EgorovA. D.

Егоров Александр Дмитриевич - к.б.н., ведущий научный сотрудник, руководитель группы.

354340, Сириус, Олимпийский проспект, д. 1

Researcher ID A-7393-2014; Scopus Author ID 55568681100

Alexander D. Egorov - PhD, Leading researcher, group leader.

1 Olympic ave., 354340 Sirius

Researcher ID A-7393-2014; Scopus Author ID 55568681100

egorov.alek@gmail.comНаправление «Медицинская биотехнология», Центр трансляционной медицины, Научно-технологический университет «Сириус»РоссияDivision of Medical Biotechnology, Research Center for Translational Medicine, Sirius University of Science and technologyRussian FederationНаправление «Генная терапия», Центр трансляционной медицины, Научно-технологический университет «Сириус»РоссияDivision of Gene Therapy, Research Center for Translational Medicine, Sirius University of Science and technologyRussian Federation202403062024213295301Copyright © Егорова В.С., Гурциева Д.Т., Егоров А.Д., 20242024Егорова В.С., Гурциева Д.Т., Егоров А.Д.Egorova V.S., Gurtsieva D.T., Egorov A.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13070

Ожирение является одной из важнейших проблем здравоохранения. Известно, что массу тела можно контролировать с помощью сочетания здорового питания и физической активности, однако гипертрофическое ожирение часто осложнено другими сопутствующими заболеваниями, такими как сахарный диабет 2 типа, сердечно-сосудистые заболевания, артериальная гипертензия и различные формы артрита. В случае, когда больным противопоказаны интенсивные физические нагрузки, могут быть разработаны альтернативные подходы для борьбы с ожирением. Открытие бежевых адипоцитов в белой жировой ткани привлекло внимание к их использованию в качестве терапевтической мишени. Существуют молекулы различной природы, которые способны модулировать процесс образования бежевых адипоцитов, взаимодействуя с критически важными сигнальными каскадами, что приводит к усилению термогенеза. В данный момент разрабатываются препараты на основе малых молекул, а также перепрограммирование с использованием инструментов генной терапии. В данном обзоре рассматривается возможность стимуляции перехода белых жировых клеток в бежевые с помощью нутриентов, а также подробно обсуждаются молекулярные мишени пищевых и синтетических малых молекул, действующих на процесс побурения жировой ткани.

Obesity is one of the most important health problems. Body weight can be controlled through a combination of a healthy diet and physical activity, but hypertrophic obesity is often complicated by other comorbidities such as type 2 diabetes mellitus (T2DM), cardiovascular disease, hypertension and various forms of arthritis. If intense physical activity is contraindicated for patients, then alternative approaches to combat obesity can be developed. The discovery of beige adipocytes in white adipose tissue has attracted attention to their use as a target for therapy. There are molecules of various origin that are capable of modulating the formation of beige adipocytes by interacting with critical signaling cascades, leading to increased thermogenesis. One such approach would be to stimulate the transition of white adipose tissue cells into more catabolically active beige cells using nutrients and small molecule drugs.

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The authors declare that there are no conflicts of interest present.