ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13019ometendo-13019Research ArticleОБЗОРЫREVIEWSОжирение и нервная системаObesity and the nervous systemhttps://orcid.org/0000-0003-2373-2231АнтоноваК. В.AntonovaK. V.

Антонова Ксения Валентиновна - доктор медицинских наук, ведущий научный сотрудник 1 неврологического отделения, врач-эндокринолог.

125367, Москва, Волоколамское шоссе, д. 80

Researcher ID: J-9971-2016; Scopus Author ID: 7004672742

Ksenia V. Antonova - MD, PhD.

80 Volokolamskoe Shosse, 125367 Moscow

Researcher ID: J-9971-2016; Scopus Author ID: 7004672742

kseniya.antonova@mail.ruhttps://orcid.org/0000-0002-5883-8119ТанашянМ. М.TanashyanM. M.

Танашян Маринэ Мовсесовна - д.м.н., профессор.

Москва

Researcher ID: F-8483-2014; Scopus Author ID: 6506228066

Marine M. Tanashyan - MD, PhD, Professor.

Moscow

Researcher ID: F-8483-2014; Scopus Author ID: 6506228066

mtanashyan@neurology.ruhttps://orcid.org/0000-0003-0522-767XРаскуражевА. А.RaskurazhevA. A.

Раскуражев Антон Алексеевич - к.м.н.

Москва

Researcher ID: K-7636-2012; Scopus Author ID: 57191092653

Anton A. Raskurazhev - MD, PhD.

Moscow

Researcher ID: K-7636-2012; Scopus Author ID: 57191092653

rasckey@live.comhttps://orcid.org/0000-0002-2934-5462СпрышковН. Е.SpryshkovN. E.

Спрышков Никита Евгеньевич.

Москва

Nikita E. Spryshkov.

Moscow

nikita_spryshkov@mail.ruhttps://orcid.org/0000-0002-8652-2947ПанинаА. А.PaninaA. A.

Панина Анастасия Андреевна.

Москва

Anastasiya A. Panina.

Moscow

nastena.panina.98@mail.ruhttps://orcid.org/0000-0001-7562-4991ЛагодаО. В.LagodaO. V.

Лагода Ольга Викторовна - к.м.н.

Москва

Researcher ID: C-5395-2012; Scopus Author ID: 6507370001

Olga V. Lagoda - MD, PhD.

Moscow

olga.lagoda@gmail.comhttps://orcid.org/0000-0002-7936-7619АметовА. С.AmetovA. S.

Аметов Александр Сергеевич - д.м.н., профессор.

Москва

Alexander S. Ametov - MD, PhD, Professor.

Moscow

alexander.ametov@gmail.comhttps://orcid.org/0000-0002-8520-8702ТрошинаЕ. А.TroshinaE. A.

Трошина Екатерина Анатольевна - д.м.н., профессор.

Москва

Ekaterina A. Troshina - MD, PhD, Professor.

Moscow

troshina@inbox.ruНаучный центр неврологииРоссияResearch Center of NeurologyRussian FederationРоссийская медицинская академия непрерывного профессионального образованияРоссияRussian Medical Academy of Continuing Professional EducationRussian FederationНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian Federation2024060320242116878Copyright © Антонова К.В., Танашян М.М., Раскуражев А.А., Спрышков Н.Е., Панина А.А., Лагода О.В., Аметов А.С., Трошина Е.А., 20242024Антонова К.В., Танашян М.М., Раскуражев А.А., Спрышков Н.Е., Панина А.А., Лагода О.В., Аметов А.С., Трошина Е.А.Antonova K.V., Tanashyan M.M., Raskurazhev A.A., Spryshkov N.E., Panina A.A., Lagoda O.V., Ametov A.S., Troshina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13019

В статье обсуждаются чрезвычайно актуальные в связи с пандемическим распространением ожирения аспекты взаимосвязи неврологических заболеваний и метаболических нарушений. Подробно рассмотрен патогенез поражения нервной системы (НС). Показано влияние основных обменных факторов на развитие цереброваскулярных заболеваний (ЦВЗ), в т.ч. нейровоспаления, изменение гемостаза и др. Освещена проблема развития когнитивной дисфункции на фоне ожирения за счет формирования атрофических процессов в структурах мозга. Описаны современные возможности оценки и модулирования пищевого поведения за счет стимуляции головного мозга с применением функциональной магнитно-резонансной томографии (фМРТ) и навигационной ритмической транскраниальной магнитной стимуляции (рТМС).

Представлена проблема цереброметаболического здоровья как единство метаболических и церебральных изменений. Механизмы взаимодействия двух важнейших систем организма позволяют рассматривать возникающие в них изменения в качестве целостной нейроэндокринной альтерации.

The article discusses certain aspects of the relationship between neurological diseases and metabolic disorders that are extremely relevant in connection with the pandemic spread of obesity. The pathogenesis of damage to the nervous system (NS) is considered in detail. The influence of the main metabolic factors on the development of cerebrovascular diseases (CVD), incl. neuroinflammation, changes in hemostasis, etc. is demonstrated. The problem of the development of cognitive dysfunction against the background of obesity due to the formation of atrophic processes in brain structures is highlighted. Modern possibilities of evaluation and modulation of eating behavior due to brain stimulation using functional magnetic resonance imaging (fMRI) and navigational rhythmic transcranial magnetic stimulation (rTMS) are described.

The problem of cerebrometabolic health is presented as a continuum of metabolic and cerebral disturbances. The mechanisms of interaction between the two most important systems of the body allow us to consider the changes that occur in them as an integral neuroendocrine alteration.

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The authors declare that there are no conflicts of interest present.