ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet12966ometendo-12997Research ArticleОБЗОРREVIEWПоствакцинальный и постинфекционный иммунитет против новой коронавирусной инфекции на фоне ожирения и избыточной массы телаPost-vaccination and post-infectious immune response against new coronavirus infection on the background of obesity and overweighthttps://orcid.org/0000-0003-1577-7077КлимчукА. В.KlimchukA. V.

Климчук Анастасия Васильевна, кандидат медицинских наук

295051, Симферополь, бульвар Ленина 5/7

 

Anastasia V. Klimchuk, MD, PhD

Simferopol

295051, Lenin boulevard 5/7, Simferopol

 

anastasiya-klim@mail.ruhttps://orcid.org/0000-0001-9640-754XБелоглазовВ. А.BeloglazovV. A.

Белоглазов Владимир Алексеевич, доктор медицинских наук, профессор

Симферополь

Scopus Author ID: 7007129056

 

Vladimir A. Beloglazov, MD, PhD, professor

Simferopol

Scopus Author ID: 7007129056;

 

biloglazov@mail.ruhttps://orcid.org/0000-0002-5486-7262ЯцковИ. А.YatskovI. A.

Яцков Игорь Анатольевич, кандидат медицинских наук

Симферополь

Scopus Author ID: 57218873902

Igor A. Yatskov, MD

Simferopol

Scopus Author ID: 57218873902;

 

egermd@yandex.ruhttps://orcid.org/0000-0001-9950-2016АгзамоваЮ. М.AgzamovaYu. M.

Агзамова Юлдуз Мансуровна, студент

Симферополь

 

Yulduz M. Agzamova, student

Simferopol

starsmile005@gmail.comhttps://orcid.org/0000-0003-1547-915XКамшийА. А.KamshiiA. A.

Камший Алина Анатольевна

Симферополь

 

Alina A. Kamshii

Simferopol

sniezhinskaia98@mail.ruhttps://orcid.org/0000-0001-9147-8461ЗаяеваА. А.ZayaevaA. A.

Заяева Анна Анатольевна, кандидат медицинских наук

Симферополь

 

Anna A. Zayaeva, MD, PhD

Simferopol

 

a.zayayeva@yandex.comМедицинская академия имени С.И. Георгиевского, Крымский федеральный университет имени В.И. ВернадскогоРоссияGeorgievsky Medical Academy, V.I. Vernadsky Crimean Federal UniversityRussian Federation2023230520232016065Copyright © Климчук А.В., Белоглазов В.А., Яцков И.А., Агзамова Ю.М., Камший А.А., Заяева А.А., 20232023Климчук А.В., Белоглазов В.А., Яцков И.А., Агзамова Ю.М., Камший А.А., Заяева А.А.Klimchuk A.V., Beloglazov V.A., Yatskov I.A., Agzamova Y.M., Kamshii A.A., Zayaeva A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/12997

Осенью 2019 г. мировое здравоохранение столкнулось с новым РНК-вирусом — коронавирусом 2 тяжелого острого респираторного синдрома SARS-CoV-2. На фоне стремительного распространения инфекции исследовательские центры всех стран мира начали разработку специфических вакцин против COVID-19, используя накопленный опыт и эмпирические данные о стереотипах строения и физиологии других вирусных агентов этого семейства (вируса тяжелого острого респираторного синдрома (SARS) и ближневосточного респираторного синдрома (MERS)). Однако еще до разработки противоковидных вакцин было высказано предположение о, вероятно, их меньшей эффективности у ряда лиц, в частности у людей, страдающих избыточной массой тела или ожирением. Эта гипотеза возникла на основании исследований прошлых лет, изучающих применение различных вакцин у данной категории пациентов, а также на основании многочисленных экспериментов на мышах, благодаря которым ученые пришли к выводу, что перманентный воспалительный процесс на фоне накопления избыточного количества жировой ткани в организме приводит к развитию иммунной дисфункции и, в результате, к сниженной локальной и системной резистентности в отношении бактериальных и вирусных агентов.

В данном литературном обзоре с использованием современных публикаций, полученных по поисковым запросам «covid-19 vaccination and obesity» и «vaccination and obesity» в базах данных PubMed и «вакцинация covid-19 и ожирение» и «вакцинация и ожирение» в базе e-Library, обсуждаются изменения в иммунном ответе как на саму инфекцию, так и иммунизацию на фоне избыточной массы тела или ожирения.

In the fall of 2019, global health was confronted with a new RNA virus — severe acute respiratory syndrome coronavirus 2 SARS-CoV-2. Against the background of the rapid spread of infection, research centers around the world began to develop specific vaccines against COVID-19, using the accumulated experience and empirical data on the stereotypes of the structure and physiology of other viral agents of this family (severe acute respiratory syndrome virus (SARS) and Middle East respiratory syndrome (MERS). However, even before the development of anti-COVID vaccines, it was suggested that they are probably less effective in a number of individuals, in particular, in people who are overweight or obese. This hypothesis arose on the basis of past studies using vaccines for other purposes in this categories of people, as well as in numerous experiments on mice, thanks to which scientists came to the conclusion that, due to an excess amount of adipose tissue in the body, there is a state of a permanent inflammatory process, some immune dysfunction, and, as a result, a reduced local and systemic response. resistance against bacterial and viral agents.

In this literature review, using current publications obtained by searching for “covid-19 vaccination and obesity” and “vaccination and obesity” in the PubMed databases and “covid-19 vaccination and obesity” and “vaccination and obesity” in the e- Library discusses changes in the immune response both to infection itself and to immunization in the presence of overweight or obesity.

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The authors declare that there are no conflicts of interest present.