ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet12985ometendo-12985Research ArticleОБЗОРREVIEWСтволовые клетки жировой ткани: роль в патогенезе ожирения и сахарного диабета 2 типаAdipose tissue — derived mesenchymal stem: a role in the pathogenesis of obesity and type 2 diabetes mellitushttps://orcid.org/0000-0003-4321-8977УчасоваЕ. Г.UchasovaE. G.

Учасова Евгения Геннадьевна, к.м.н.

eLibrary SPIN: 1539-5332

650002, Кемерово, Сосновый бульвар, д. 6

Evgenia G. Uchasova, MD, PhD

6, Sosnovyy Bul’var, 650002 Kemerovo

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evg.uchasova@yandex.ruhttps://orcid.org/0000-0002-6890-3287ДылеваЮ. А.DylevaYu. A.

Дылева Юлия Александровна, к.м.н.

Кемерово

Yulia A. Dyleva, MD, PhD

Kemerovo

 

dyleva87@yandex.ruhttps://orcid.org/0000-0003-3996-3325БеликЕ. В.BelikE. V.

Белик Екатерина Владимировна, к.м.н.

eLibrary SPIN: 5705-9143

Кемерово

Ekaterina V. Belik, MD, PhD

Kemerovo

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sionina.ev@mail.ruhttps://orcid.org/0000-0002-7780-829XГруздеваО. В.GruzdevaO. V.

Груздева Ольга Викторовна, д.м.н., профессор

eLibrary SPIN: 4322-0963

Кемерово

Olga V. Gruzdeva, МD, PhD, professor

Kemerovo

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o_gruzdeva@mail.ruНаучно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийРоссияResearch Institute for Complex Issues of Cardiovascular DiseasesRussian Federation202327072023203245250Copyright © Учасова Е.Г., Дылева Ю.А., Белик Е.В., Груздева О.В., 20232023Учасова Е.Г., Дылева Ю.А., Белик Е.В., Груздева О.В.Uchasova E.G., Dyleva Y.A., Belik E.V., Gruzdeva O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/12985

Мезенхимальные стволовые клетки, полученные из жировой ткани, представляют собой взрослые стволовые клетки, наделенные мультипотентными способностями и иммуномодулирующими свойствами, как и мезенхимальные стволовые клетки другого происхождения. Многочисленные исследования показывают, что стволовые клетки жировой ткани участвуют в патологическом процессе могут проявлять провоспалительные свойства и привлекать воспалительные иммунные клетки по соседству. Впоследствии воспаление создает микросреду, приводящую к дисфункции жировой ткани. Примерами такого процесса являются ожирение и сахарный диабет 2 типа, при котором нарушается адипогенез и инициируется резистентность к инсулину. Цель этого обзора состоит в том, чтобы понять роль стволовых клеток жировой ткани в патогенезе ожирения и сахарного диабета 2 типа.

Adipose tissue-derived mesenchymal stem are adult stem cells endowed with multipotent abilities and immunomodulatory properties, like mesenchymal stem cells of other origins. Numerous studies show that adipose tissue stem cells are involved in the pathological process and can exhibit pro-inflammatory properties and attract inflammatory immune cells in the neighborhood. Subsequently, inflammation creates a microenvironment leading to adipose tissue dysfunction. Examples of such a process are obesity and type 2 diabetes mellitus, in which adipogenesis is disrupted and insulin resistance is initiated. The aim of this review is to understand the role of adipose tissue stem cells in the pathogenesis of obesity and type 2 diabetes mellitus.

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The authors declare that there are no conflicts of interest present.