ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet12863ometendo-12863Research ArticleОБЗОРЫREVIEWSЦитокины и регуляция метаболизма глюкозы и липидов при ожиренииCytokines and regulation of glucose and lipid metabolism in the obesityhttps://orcid.org/0000-0002-0261-970XЩербаковВ. И.ScherbakovV. I.

Щербаков Владимир Иванович, доктор медицинских наук 

Новосибирск

Vladimir I. Scherbakov, MD, PhD

Novosibirsk

Scherbakov_VI@mail.ruhttps://orcid.org/0000-0001-5477-3445СкосыреваГ. А.SkosyrevaG. A.

Скосырева Галина Александровна, доктор медицинских наук 

Новосибирск

Galina А. Skosyreva, MD, PhD

Novosibirsk

skosyreva43@mail.ruhttps://orcid.org/0000-0002-0990-0078РябиченкоТ. И.RyabichenkoT. I.

Рябиченко Татьяна Ивановна, доктор медицинских наук 

630108, Новосибирск, 1-й переулок Пархоменко, д. 6 

 

Tatyana I. Ryabichenko, MD, PhD

6, 1 Per. Parchomenko, 630108 Novosibirsk

 

2925871@mail.ruhttps://orcid.org/0000-0002-9834-1799ОбуховаО. О.ObukhovaO. O.

Обухова Ольга Олеговна, доктор медицинских наук 

Новосибирск

Olga O. Obukhova, MD, PhD

Novosibirsk

trio188@yandex.ruФедеральный исследовательский центр Фундаментальной и трансляционной медициныFederal Research Center of Fundamental and Translational Medicine202206122022193317323Copyright © Щербаков В.И., Скосырева Г.А., Рябиченко Т.И., Обухова О.О., 20232023Щербаков В.И., Скосырева Г.А., Рябиченко Т.И., Обухова О.О.Scherbakov V.I., Skosyreva G.A., Ryabichenko T.I., Obukhova O.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/12863

В статье представлены данные о влиянии роли цитокинов различной направленности на метаболизм глюкозы и липидов при ожирении. Изменение основной парадигмы в отношении жировой ткани способствовало ряду открытий последнего времени. Это касается таких базовых понятий, как здоровый и больной адипоцит, и, как следствие этого, изменения их метаболизма при воздействии цитокинов. Выделение такого понятия, как органокины, показывает, что, несмотря на общие черты цитокиновой регуляции, в каждом органе существует своя специфика, важным разделом которой является представление о гетерогенности жировой ткани. Расширяются знания о функции жировой ткани, локализованной в различных компартментах организма. Представлены данные, показывающие возможность перехода одного вида жировой ткани в другую. Показан возможный механизм, связывающий воспаление жировой ткани и формирование инсулинорезистентности. Механизм развития инсулинорезистентности тесно связан с провоспалительными цитокинами, нарушающими прохождение инсулинового сигнала, сопровождающегося снижением работы глюкозных транспортеров. Уменьшение поступления глюкозы в клетки ведет к изменению уровня гликолиза, повышению окисления жирных кислот. Цитокины способны участвовать в процессе конверсии одних клеток в другие, что происходит как при физиологическом, так и патологическом процессе.

 

The article presents data of the influence of cytokines of different directions of glucose and lipid metabolism in obesity. A change of the basic paradigm regarding adipose tissue has contributed to a number of recent discoveries. This concerns such basic concepts as healthy and diseased adipocytes, and, as a consequence, changes of their metabolism under the influence of cytokins. Distinguishing the concept of organokines demonstrates that despite the common features of cytokine regulation, each organ has its own specifics features of cytokine regulation, each organ has its own specific an important section of this concept is the idea of the heterogeneity of adipose tissue. Knowledge of the function of adipose tissue localized in different compartments of the body is expanding. There are date about the possibility of transition of one type of adipose tissue to another. A possible mechanism linking adipose tissue inflammation and the formation of insulin resistance (IR) is presented in this paper. The mechanism of IR development is closely connected with to proinflammatory cytokins disordering the insulin signal, accompanied by a decrease of the work of glucose transporters. A decrease of the income of glucose into cells leads to a change of glycolysis level to an increase of the fatty acids oxidation. Cytokins are able to participate in the process of the collaboration of some cells with others, that occurs both during physiological and pathological process.

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The authors declare that there are no conflicts of interest present.