ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet12752ometendo-12752Research ArticleОБЗОРЫREVIEWSРоль системы апелин/APJ в регуляции водного обменаThe role of the apelin/APJ system in water homeostasis regulationhttps://orcid.org/0000-0001-7566-8214ФаргиеваХ. Р.FargievaKh. R.

Фаргиева Хава Романовна, аспирант 

Москва

eLibrary SPIN:  3476-5134;

Khava R. Fargieva, MD, postgraduate student

Moscow

eLibrary SPIN: 3476-5134

khavafar95@gmail.comhttps://orcid.org/0000-0002-8694-2474ГусейноваР. М.GuseinovaR. M.

Гусейнова Раисат Магомедкамиловна

Москва

eLibrary SPIN: 9719-3850

Raisat M. Guseinova, MD

Moscow

eLibrary SPIN: 9719-3850

rasgus-9@mail.ruhttps://orcid.org/0000-0001-6539-466XПигароваЕ. А.PigarovaE. A.

Пигарова Екатерина Александровна, доктор медицинских наук

Москва

Scopus Author ID 55655098500;

Researcher ID: T-9424-2018;

eLibrary SPIN: 6912-6331

Ekaterina A. Pigarova, MD, PhD

Moscow

Scopus Author ID 55655098500;

Researcher ID: T-9424-2018;

eLibrary SPIN: 6912-6331

kpigarova@gmail.comhttps://orcid.org/0000-0002-0327-4619ДзерановаЛ. К.DzeranovaL. K.

Дзеранова Лариса Константиновна, доктор медицинских наук 

Москва

eLibrary SPIN: 2958-5555

Larisa K. Dzeranova, MD, PhD

Moscow

eLibrary SPIN: 2958-5555

dzeranovalk@yandex.ruНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian Federation202205122022193340347Copyright © Фаргиева Х.Р., Гусейнова Р.М., Пигарова Е.А., Дзеранова Л.К., 20232023Фаргиева Х.Р., Гусейнова Р.М., Пигарова Е.А., Дзеранова Л.К.Fargieva K.R., Guseinova R.M., Pigarova E.A., Dzeranova L.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/12752

Водный баланс в организме достигается путем уравновешивания почечных и непочечных потерь воды с соответствующим ее потреблением. Он находится под контролем как центральной нервной системы, которая интегрирует множество параметров водно-электролитного баланса в организме, в том числе индуцирует важные приспособительные поведенческие реакции, так и трех гормональных систем: вазопрессинергической, ренин-ангиотензин-альдостероновой и апелинергической. Множество исследований посвящено регуляции водно-электролитного обмена. Однако до сих пор этот процесс остается достаточно сложным для понимания, тем более что со временем открывается все больше его регуляторов. Одним из них является гормон апелин — эндогенный лиганд к рецептору APJ. Как известно, рецептор интенсивно экспрессируется во многих органах, таких как головной мозг, сердце, печень и почки, легкие и оказывает разнонаправленные эффекты.

В данном обзоре литературы подробно обсуждаются основные характеристики и особенности регуляции вышеобозначенных систем применительно к водно-электролитному обмену, а также вопросы межсистемного взаимодействия и модулирования эффектов апелина.

Water balance in the body is achieved by balancing renal and non-renal water losses with corresponding water intake. It is under the control of both the central nervous system, which integrates many parameters of water and electrolyte balance in the body, including inducing important adaptive behavioral responses, and three hormonal systems: vasopressinergic, renin-angiotensin-aldosterone and apelinergic. A lot of research is devoted to the regulation of water-electrolyte metabolism. However, this process is still quite difficult to understand, especially since more and more of its regulators are being discovered over time. One of them is the hormone apelin, an endogenous ligand for the APJ receptor. As is known, the receptor is highly expressed in many organs, such as the brain, heart, liver and kidneys, lungs, and has multidirectional effects.

This literature review discusses the main characteristics and features of the regulation of these systems in relation to water-electrolyte metabolism, as well as issues of intersystem interaction and modulation of the effects of apelin.

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The authors declare that there are no conflicts of interest present.