ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet12750ometendo-12750Research ArticleНаучные обзорыReviewsМетаболическая эндотоксинемия: возможные причины и последствияMetabolic endotoxemia: possible causes and consequenceshttps://orcid.org/0000-0001-9640-754XБелоглазовВ. А.BeloglazovV. A.

Белоглазов Владимир Алексеевич, д.м.н., профессор; Scopus Author ID: 7007129056; eLibrary SPIN: 7455-2188

Симферополь

Vladimir A. Beloglazov, MD, PhD, Professor

Simferopol

biloglazov@mail.ruhttps://orcid.org/0000-0002-5486-7262ЯцковИ. А.YatskovI. A.

Яцков Игорь Анатольевич; Scopus Author ID: 57218873902; eLibrary SPIN: 2395-5710

Россия, 295491, Симферополь, ул. Мальченко, д. 7

Igor A. Yatskov, MD; Scopus Author ID: 57218873902; eLibrary SPIN: 2395-5710

Simferopol

egermd@yandex.ruhttps://orcid.org/0000-0001-5090-4516КумельскийЕ. Д.KumelskyE. D.

Кумельский Евгений Дмитриевич, аспирант; eLibrary SPIN: 7455-2188

 

 

Evgeny D. Kumelsky, postgraduate student

Simferopol

ekum.rk@yandex.ruhttps://orcid.org/0000-0002-3567-6532ПоловинкинаВ. В.PolovinkinaV. V.

Половинкина Валерия Владимировна, студент

Симферополь

Valeria V. Polovinkina, student

Simferopol

wwaa.po@gmail.comКрымский федеральный университет имени В.И. Вернадского, Медицинская академия имени С.И. ГеоргиевскогоРоссияV.I. Vernadsky Crimean Federal University, S.I. Georgievsky Medical AcademyRussian Federation202107072021183320326Copyright © Белоглазов В.А., Яцков И.А., Кумельский Е.Д., Половинкина В.В., 20212021Белоглазов В.А., Яцков И.А., Кумельский Е.Д., Половинкина В.В.Beloglazov V.A., Yatskov I.A., Kumelsky E.D., Polovinkina V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/12750

В данной обзорной статье представлены сведения из литературных источников, которые дают представление о связи метаболических нарушений, возникающих на фоне ожирения, с эндотоксинемией, а также влиянии этих состояний на поддержание низкоинтенсивного воспаления в организме. Приведено описание гормональной и иммунной перестройки белой жировой ткани, основных путей поступления и метаболизма эндотоксина. Особое внимание уделено механизмам взаимного влияния ожирения и эндотоксинемии. Описанные М.Ю. Яковлевым в 1988 г. «эндотоксиновая агрессия» и P.D. Cani и соавт. в 2007 г. «метаболическая эндотоксинемия», на наш взгляд, являются одними из важнейших триггеров развития и прогрессирования целого спектра острых и хронических заболеваний. Исходя из данных последних лет, жировая ткань представляет собой активный эндокринный орган, способный оказывать влияние как на обменные процессы, так и на состояние врожденных и приобретенных механизмов иммунной защиты. В настоящее время доказано, что высококалорийные диеты приводят к увеличению не только избыточной массы тела, но и уровня циркулирующего в крови эндотоксина. Углубленное изучение способности ожирения и эндотоксинемии потенцировать взаимное провоспалительное действие может помочь как в понимании патогенеза основных сердечно-сосудистых, аутоиммунных, аллергических и инфекционных (в том числе вирусных) заболеваний, так и в разработке методов нефармакологической и медикаментозной коррекции данных состояний.

This review article presents data from the literature, which provide an idea of the relationship between metabolic disorders occurring against the background of obesity and endotoxinemia, as well as the effect of these conditions on the maintenance of low-grade inflammation in the body. A description of the hormonal and immune restructuring of white adipose tissue, the main routes of entry and metabolism of endotoxin is given. Particular attention is paid to the mechanisms of the mutual influence of obesity and endotoxinemia. Described by Yakovlev M.Yu. in 1988 «endotoxin aggression» and Cani P.D. et al. in 2007, «metabolic endotoxinemia», in our opinion, is one of the most important triggers for the development and progression of a whole spectrum of acute and chronic diseases. Based on the data of recent years, adipose tissue is an active endocrine organ capable of influencing both metabolic processes and the state of innate and acquired immune defense mechanisms. It has now been proven that high-calorie diets lead not only to an increase in overweight, but also to an increase in the level of endotoxin circulating in the blood. An in-depth study of the ability of obesity and endotoxinemia to potentiate the mutual pro-inflammatory effect can help both in understanding the pathogenesis of the main cardiovascular, autoimmune, allergic and infectious (including viral) diseases, and in the development of methods for non-pharmacological and drug correction of these conditions.

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The authors declare that there are no conflicts of interest present.