ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet12734ometendo-12734Research ArticleНаучные исследованияOriginal studiesПоказатели качества эякулята мужчин с астенозооспермией и астенотератозооспермией на фоне лечения ожирения лираглутидомEjaculate quality indicators of men with asthenozoospermia and asthenoteratozoospermia by treatment of obesity with liraglutidehttps://orcid.org/0000-0002-7145-8954БобковД. Н.BobkovD. N.

Бобков Даниил Николаевич; eLibrary SPIN: 5311-5050

Россия, 117036, Москва, ул. Дм. Ульянова, д. 11

Daniil N. Bobkov, MD

11 Dm. Ulyanova street, 117036 Moscow, Russia

danil-0000@mail.ruhttps://orcid.org/0000-0002-5386-4289РоживановР. В.RozhivanovR. V.

Роживанов Роман Викторович, д.м.н.; eLibrary SPIN: 8052-3310

Москва

Roman V. Rozhivanov, MD, PhD

Moscow

rrozhivanov@mail.ruhttps://orcid.org/0000-0002-7916-0212ВитязеваИ. И.VityazevaI. I.

Ирина Ивановна Витязева; eLibrary SPIN: 6331-2217

Москва

Irina I. Vityazeva, MD, PhD

Moscow

vitiazeva@yandex.ruНациональный медицинский исследовательский центр эндокринологииРоссияEndocrinology Research CentreRussian Federation202131082021183263267Copyright © Бобков Д.Н., Роживанов Р.В., Витязева И.И., 20212021Бобков Д.Н., Роживанов Р.В., Витязева И.И.Bobkov D.N., Rozhivanov R.V., Vityazeva I.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/12734Обоснование

Обоснование. Учитывая роль висцерального ожирения в развитии мужского бесплодия, актуально исследование показателей качества эякулята на фоне фармакотерапии ожирения.

Цель

Цель. Оценка показателей качества эякулята на фоне лечения ожирения лираглутидом у мужчин с бесплодием, постпубертатным висцеральным ожирением и неотягощенным андрологическим анамнезом.

Методы

Методы. В пилотное наблюдательное проспективное исследование были включены бесплодные мужчины с постпубертатным алиментарным висцеральным ожирением. Всем пациентам были даны рекомендации по снижению массы тела (гипокалорийное питание, ежедневные аэробные физические нагрузки, а также лираглутид в средней дозе 2,4 [2,4; 3,0] мг). Проводилась оценка окружности талии, антиоксидантной активности эякулята, спермограммы исходно и в динамике через 6 мес. Статистически значимыми считали различия при p<0,005.

Результаты

Результаты. Снижение массы тела составило -11,7 [12,4; 11,0]% от исходного, окружность талии уменьшилась на 8 [12; 7] см. При оценке динамики были отмечены статистически значимые: увеличение содержание в эякуляте живых сперматозоидов от 92 [90; 95]% до 95 [92; 98]%, их морфологически нормальных форм от 5 [3; 6]% до 6 [3; 8]%, подвижности А+В от 25 [15; 36] до 35 [19; 52]%, а также антиоксидативной активности эякулята, уменьшение активных форм кислорода в нативном эякуляте, чего не отмечалось в отношении активных форм кислорода в отмытых сперматозоидах. Увеличение количества сперматозоидов в 1 мл эякулята статистической значимости не достигло.

Заключение

Заключение. У молодых мужчин с постпубертатным висцеральным ожирением и неотягощенным андрологическим анамнезом показатели качества эякулята на фоне комплексного лечения ожирения с применением лираглутида улучшились.

Background

Background: Considering the influence of visceral obesity on male infertility, the investigation of ejaculate quality indicators under obesity treatment is relevant.

Objective

Objective: Evaluation of ejaculate quality indicators by obesity treatment with liraglutide in andrologically healthy men with infertility and post-pubertal visceral obesity.

Methods

Methods: Infertile men with post-pubertal alimentary visceral obesity were included in a pilot observational prospective study. All patients were given recommendations for body weight loss (hypocaloric diet, daily aerobic physical activity) as well as an average daily dose of liraglutide 2.4 [2.4; 3.0] mg. Evaluation of waist circumference, antioxidant activity of ejaculate, spermogram was carried out initially and after 6 months. The differences were considered statistically significant at p <0.005.

Results

Results: The body weight decrease was -11.7 [12.4; 11.0]%, the waist circumference decrease was 8 [12; 7] cm. In dynamics, increased content of living sperm in ejaculate from 92 [90; 95]% to 95 [92; 98]%, morphologically normal forms from 5 [3; 6]% to 6 [3; 8]%, mobility of A + B from 25 [15; 36] to 35 [19; 52]%, seminal antioxidant capacity, a decrease in reactive oxygen forms in the neat ejaculate were statistically significant. Increasing the sperm count in 1 ml and decreasing reactive oxygen forms in the washed ejaculate did not reach statistical significance.

Conclusion

Conclusion: Ejaculate quality indicators improved by the complex obesity therapy with liraglutide in young andrologically healthy men with postpubertal visceral obesity.

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The authors declare that there are no conflicts of interest present.