ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet12704ometendo-12704Research ArticleНаучные обзорыReviewsРаспространенность и биомаркеры метаболического синдромаPrevalence and biomarkers in metabolic syndromehttps://orcid.org/0000-0001-5018-0271КытиковаО. Ю.KytikovaO. Y.

Кытикова Оксана Юрьевна, д.м.н.; eLibrary SPIN: 3006-5614

Россия, 690105, Владивосток, ул. Русская, д. 73 Г

Oxana Yu. Kytikova, MD, PhD

73 G Russkaya street, 690105, Vladivostok, Russia

kytikova@yandex.ruhttps://orcid.org/0000-0002-2492-3198АнтонюкМ. В.AntonyukM. V.

Антонюк Марина Владимировна, д.м.н., профессор; eLibrary SPIN: 3446-4852

Владивосток

Marina V. Antonyuk, MD, PhD, Professor

Vladivostok

antonyukm@mail.ruhttps://orcid.org/0000-0002-7851-6141КантурТ. А.KanturT. A.

Кантур Татьяна Александровна, к.м.н.; eLibrary SPIN: 7889-7290

Владивосток

Tatyana A. Kantur, MD, PhD

Vladivostok

kanturovichi@yandex.ruhttps://orcid.org/0000-0002-6058-201XНовгородцеваТ. П.NovgorodtsevaT. P.

Новгородцева Татьяна Павловна, д.б.н., профессор; eLibrary SPIN: 5888-6099

Владивосток

Tatyana Р. Novgorodtseva, MD, PhD, Professor

Vladivostok

nauka@niivl.ruhttps://orcid.org/0000-0003-4130-8899ДенисенкоЮ. К.DenisenkoY. K.

Денисенко Юлия Константиновна, д.б.н.; eLibrary SPIN-код: 4997-3432

Владивосток

Yuliya К. Denisenko, MD, PhD

Vladivostok

karaman@inbox.ruДальневосточный научный центр физиологии и патологии дыханияРоссияFar Eastern Scientific Centre of Physiology and Pathology of RespirationRussian FederationДальневосточный федеральный университетРоссияFar Eastern Scientific Centre of Physiology and Pathology of RespirationRussian FederationДальневосточный научный центр физиологии и патологии дыханияRussian Federation202131082021183302312Copyright © Кытикова О.Ю., Антонюк М.В., Кантур Т.А., Новгородцева Т.П., Денисенко Ю.К., 20212021Кытикова О.Ю., Антонюк М.В., Кантур Т.А., Новгородцева Т.П., Денисенко Ю.К.Kytikova O.Y., Antonyuk M.V., Kantur T.A., Novgorodtseva T.P., Denisenko Y.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/12704

Распространенность метаболического синдрома (МС) имеет мировую тенденцию к увеличению и зависит от многих составляющих, что объясняет сложности диагностики и подходов к профилактике и лечению данной патологии. Возраст, образ жизни, социально-экономический статус, инсулинорезистентность (ИР), дислипидемия, ожирение и генетическая предрасположенность являются факторами, влияющими на риск развития и прогрессирования МС. Особенности распределения жировой ткани и ее дисфункция — важные факторы развития ИР с ожирением, а также риска формирования кардиометаболических заболеваний и МС. Понимание данных механизмов связывают с достижениями в области метаболического фенотипирования. Метаболическое фенотипирование лиц, страдающих ожирением, важно в отношении изучения патофизиологии нарушений обмена веществ, возможного сопутствующего заболевания и поиска инновационных стратегий профилактики и лечения МС. Поэтому актуальность дальнейшего изучения патофизиологических механизмов, лежащих в основе различных метаболических фенотипов МС, является одним из перспективных направлений современных научных исследований. В настоящем обзоре суммированы современные литературные данные о распространенности МС в зависимости от пола, возраста, популяции, территории проживания, образования, уровня физической активности и многих других параметров. Детализированы метаболические риски развития МС. Рассмотрены биологические маркеры МС. Показана необходимость метаболического фенотипирования МС, которое может иметь потенциальное терапевтическое значение.

The prevalence of metabolic syndrome (MS) has a worldwide tendency to increase and depends on many components, which explains the complexity of diagnostics and approaches to the prevention and treatment of this pathology. Age, lifestyle, socioeconomic status, insulin resistance (IR), dyslipidemia, obesity and genetic predisposition are factors influencing the risk of developing and progression of MS. Features of the distribution and dysfunction of adipose tissue are important factors in the development of IR, with obesity, as well as the risk of the formation of cardiometabolic diseases and MS. ­Understanding of mechanisms is linked to advances in metabolic phenotyping. Metabolic phenotyping of obese persons is important for the development of important diseases in relation to the study of the pathophysiology of metabolic disorders, the possible concomitant disease and the search for innovative strategies for the prevention and treatment of MS. The understanding of MS mechanisms is associated with advances in metabolic phenotyping. Therefore, the relevance of further study of the pathophysiological mechanisms underlying various metabolic phenotypes of MS is one of the promising areas of modern scientific research. This review summarizes the current literature data on the prevalence of MS depending on gender, age, population, area of residence, education, level of physical activity, and many other parameters. Metabolic risks of MS development are detailed. Biological markers of MS are considered. The necessity of metabolic phenotyping of MS has been shown, which may have potential therapeutic value.

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The authors declare that there are no conflicts of interest present.