ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet12517ometendo-12517Research ArticleОбзор литературыReviewПсориаз и метаболический синдром: обзор литературыPsoriasis and metabolic syndrome: a reviewhttps://orcid.org/0000-0002-4335-9334УфимцеваМ. А.UfimtsevaM. A.

Уфимцева Марина Анатольевна, доктор медицинских наук, профессор

Екатеринбург

eLibrary SPIN: 4753-7210

Marina A. Ufimtseva, MD, PhD, Professor

Yekaterinburg

eLibrary SPIN: 4753-7210

mail-m@mail.ruhttps://orcid.org/0000-0001-6216-2468ПоповА. А.PopovA. A.

Попов Артем Анатольевич, доктор медицинских наук, доцент

Екатеринбург

eLibrary SPIN: 5083-9389

Artem A. Popov, MD, PhD

Yekaterinburg

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art_popov@mail.ruhttps://orcid.org/0000-0001-7173-7091ФедотоваЛ. В.FedotovaL. V.

Федотова Лариса Валентиновна, кандидат медицинских наук

Екатеринбург

eLibrary SPIN: 5548-7201

 

Larisa V. Fedotova, MD, PhD

Yekaterinburg

eLibrary SPIN: 5548-7201

medlight65@mail.ruhttps://orcid.org/0000-0001-8620-4044МыльниковаЕ. С.MylnikovaE. S.

Мыльникова Екатерина Сергеевна, ординатор

620028, г. Екатеринбург, ул. Репина, д. 3

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Ekaterina S. Mylnikova, resident

3 Repina street, 620028, Yekaterinburg

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shadael96@mail.ruhttps://orcid.org/0000-0001-6298-7216БочкаревЮ. М.BochkarevYu. M.

Бочкарев Юрий Михайлович, кандидат медицинских наук, доцент

Екатеринбург

eLibrary SPIN: 3830-2810

Yuri M. Bochkarev, MD, PhD

Yekaterinburg

eLibrary SPIN: 3830-2810

bochkarev.ju.m@gmail.comhttps://orcid.org/0000-0002-9265-4751ЖунисоваД. С.ZhunisovaD. S.

Жунисова Динара Сакеновна, аспирант

Екатеринбург

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Dinara S. Zhunisova, postgraduate student

Yekaterinburg

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dinara2690dvk@mail.ruУральский государственный медицинский университетРоссияUrals State Medical UniversityRussian Federation202025122020174369374Copyright © Уфимцева М.А., Попов А.А., Федотова Л.В., Мыльникова Е.С., Бочкарев Ю.М., Жунисова Д.С., 20202020Уфимцева М.А., Попов А.А., Федотова Л.В., Мыльникова Е.С., Бочкарев Ю.М., Жунисова Д.С.Ufimtseva M.A., Popov A.A., Fedotova L.V., Mylnikova E.S., Bochkarev Y.M., Zhunisova D.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/12517

Псориаз является самым распространенным хроническим дерматозом и встречается у 1–2% населения развитых стран. В Российской Федерации отмечается прирост заболеваемости на 11% за период с 2011 по 2018 гг. Псориаз — хроническое иммуновоспалительное заболевание кожи — часто ассоциируется с полным метаболическим синдромом или его компонентами: ожирением, артериальной гипертензией, инсулинорезистентностью, дислипидемией. Риск развития метаболического синдрома у пациентов с псориазом на 40% выше, чем в общей популяции. Общими звеньями патогенеза псориаза и метаболического синдрома являются хроническое системное вялотекущее воспаление и повышение уровня провоспалительных цитокинов. Системное воспаление способствует развитию ожирения, заболеваний сердечно-сосудистой системы, сахарного диабета 2 типа. Эти состояния приводят к повышению смертности среди пациентов с псориазом. Существует положительная связь между тяжестью течения псориаза и наличием метаболического синдрома, что проявляется большей распространенностью высыпаний, сокращением сроков ремиссии и повышенным риском развития псориатического артрита. У носителей аллелей риска ожирения гена FTO наблюдается более тяжелое течение псориаза, наличие псориатического артрита, повышение индекса массы тела. В статье представлен обзор литературы, посвященный вопросам эпидемиологии, этиологии, патогенеза псориаза и метаболического синдрома.

Psoriasis is the most common chronic dermatosis and affects 1–2% of the population of developed countries. In Russia, psoriasis incidence rate has increased by 11% since 2011. Psoriasis is a chronic inflammatory and immune-mediated skin disease and it is often associated with metabolic syndrome and its components such as obesity, arterial hypertension, insulin resistance and dyslipidemia. The risk of developing metabolic syndrome in patients with psoriasis is 40% higher than in the general population. Psoriasis and metabolic syndrome share some pathogenic mechanisms such as chronic low-grade systemic inflammation and an increased level of pro-inflammatory cytokines. Systemic inflammation causes obesity, cardiovascular diseases, diabetes. These conditions increase the risk of mortality among patients. There is a link between the severity of psoriasis and metabolic syndrome and associated with severe rash, reduction of the remission and higher risk of psoriatic arthritis development. The carriers of the risk allele of FTO gene are associated with severe psoriasis, presence of psoriatic arthritis and obesity. The article presents the issues of epidemiology, etiology and pathogenesis of psoriasis and metabolic syndrome.

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The authors declare that there are no conflicts of interest present.