ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet12279ometendo-12279Research ArticleНаучные обзорыReviewsЗначение мелатонина в регуляции метаболизма, пищевого поведения, сна и перспективы его применения при экзогенно-конституциональном ожиренииThe importance of melatonin in the regulation of metabolism, eating behavior, sleep, and the prospects for the use of melatonin drugs for obesity treatmenthttps://orcid.org/0000-0002-5421-0981ЦветковаЕ. С.TsvetkovaE. S.

Цветкова Евдокия Сергеевна - eLibrary SPIN: 9047-4183.

119991, ул. Б. Пироговская, д. 2, стр. 4, Москва

Evdokiia S. Tsvetkova - MD, eLibrary SPIN: 9047-4183

2-4 Bolshaya Pirogovskaya st., 119991 Moscow

evatsvetkova.md@gmail.comhttps://orcid.org/0000-0003-3870-6394РоманцоваТ. И.RomantsovaT. I.

Романцова Татьяна Ивановна - доктор медицинских наук, профессор; eLibrary SPIN: 3855-5410.

Москва

Tatiana I. Romantsova, MD, PhD, professor; eLibrary SPIN: 3855-5410.

Moscow

romantsovatatiana@rambler.ruhttps://orcid.org/0000-0001-6215-0918ПолуэктовМ. Г.PoluektovM. G.

Полуэктов Михаил Гурьевич - кандидат медицинских наук; eLibrary SPIN: 7539-9525.

Москва

Mikhail G. Poluektov, MD, PhD; eLibrary SPIN: 7539-9525

Moscow

polouekt@mail.ruhttps://orcid.org/0000-0003-2144-8595РуноваГ. Е.RunovaG. E.

Рунова Гюзель Евгеньевна - кандидат медицинских наук, Guzel E. Runova, MD, PhD];

Москва

Guzel E. Runova, MD, PhD; eLibrary SPIN: 3639-6932.

Moscow

guzelvolkova@yandex.ruhttps://orcid.org/0000-0001-8505-5526ГлинкинаИ. В.GlinkinaI. V.

Глинкина Ирина Владимировна - кандидат медицинских наук; eLibrary SPIN: 2731-2400.

Москва

Irina V. Glinkina, MD, PhD; eLibrary SPIN: 2731-2400

Moscow

irina_glinkina@rambler.ruhttps://orcid.org/0000-0002-3026-6315ФадеевВ. В.FadeevV. V.

Фадеев Валентин Викторович - доктор медицинских наук, профессор; eLibrary SPIN: 6825-8417

Москва

Valentin V. Fadeev, MD, PhD, professor; eLibrary SPIN: 6825-8417

Moscow

walfad@mail.ruПервый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian FederationПервый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияI. M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation202123072021182112124Copyright © Цветкова Е.С., Романцова Т.И., Полуэктов М.Г., Рунова Г.Е., Глинкина И.В., Фадеев В.В., 20212021Цветкова Е.С., Романцова Т.И., Полуэктов М.Г., Рунова Г.Е., Глинкина И.В., Фадеев В.В.Tsvetkova E.S., Romantsova T.I., Poluektov M.G., Runova G.E., Glinkina I.V., Fadeev V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/12279

Мелатонин является уникальным гормоном и хронобиотиком, синхронизирующим эндогенные циркадианные ритмы организма, его физиологию и поведение с окружающей средой. Современный урбанизированный уклад общества и процессы промышленного производства напрямую зависят от наличия искусственного освещения в ночное время и включают распространенное использование электронных устройств, экраны которых излучают свет синего спектра. Наличие освещения в ночные часы задерживает начало секреции мелатонина в организме и снижает его пик, вызывая хроническую гипомелатонинемию. Гипомелатонинемия совместно с вызываемыми ей депривацией сна, нарушением пищевого поведения, углеводного и жирового обмена является одной из причин «неинфекционной эпидемии XXI в.» — экзогенно-конституционального ожирения. Учитывая это, применение препаратов мелатонина для коррекции гипомелатонинемии у лиц с экзогенно-конституциональным ожирением может иметь определенные перспективы. Неоднократно была показана эффективность подобных препаратов в испытаниях in vitro и на животных моделях, есть данные о влиянии препаратов мелатонина на снижение массы тела и резистентности к инсулину у человека. Для подтверждения гипотезы о перспективах их применения требуются дальнейшие проспективные контролируемые рандомизированные исследования в этой области.

Melatonin is a special hormone that act as an internal synchronizer of circadian rhythms, the organism physiology and behavior to the environmental day and night and seasons of the year. The present urban society and the industrial production processes as organized should be considered, as both depend on the presence of indoor lights during the night and include the profuse use of electronic devices whose screens are rich in blue wavelength light. Light during the night delays the beginning of the secretory episode of melatonin and blunts its peak, causing chronic hypomelatoninemia. Hypomelatonemia, that causes deprivation of sleep and eating behavior disorders, along with low physical activity, can be the reason of the obesity, «non-infectious epidemic of the 21st century». According to this, the use of melatonin drugs for obesity treatment can be effective. Further prospective, controlled, randomized trials in this area are required to confirm this hypothesis.

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The authors declare that there are no conflicts of interest present.