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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ometendo</journal-id><journal-title-group><journal-title xml:lang="ru">Ожирение и метаболизм</journal-title><trans-title-group xml:lang="en"><trans-title>Obesity and metabolism</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2071-8713</issn><issn pub-type="epub">2306-5524</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/omet10340</article-id><article-id custom-type="elpub" pub-id-type="custom">ometendo-10340</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзор литературы</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Ожирение – угроза репродуктивного потенциала России</article-title><trans-title-group xml:lang="en"><trans-title>Obesity – threat to the reproductive potential of Russia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8425-0020</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреева</surname><given-names>Елена Николаевна</given-names></name><name name-style="western" xml:lang="en"><surname>Andreeva</surname><given-names>Elena N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф.&#13;
&#13;
</p></bio><bio xml:lang="en"><p>MD, PhD, Professor</p></bio><email xlink:type="simple">endogin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7177-0254</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шереметьева</surname><given-names>Екатерина Викторовна</given-names></name><name name-style="western" xml:lang="en"><surname>Sheremetyeva</surname><given-names>Ekaterina V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>MD, PhD</p></bio><email xlink:type="simple">s1981k@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0517-8687</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фурсенко</surname><given-names>Валентина Алексеевна</given-names></name><name name-style="western" xml:lang="en"><surname>Fursenko</surname><given-names>Valentina A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант</p></bio><bio xml:lang="en"><p>MD, postgraduate student</p></bio><email xlink:type="simple">dr.v1@bk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России; ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Endocrinology Research Centre; A.I. Yevdokimov Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Endocrinology Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>21</day><month>12</month><year>2019</year></pub-date><volume>16</volume><issue>3</issue><fpage>20</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Андреева Е.Н., Шереметьева Е.В., Фурсенко В.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Андреева Е.Н., Шереметьева Е.В., Фурсенко В.А.</copyright-holder><copyright-holder xml:lang="en">Andreeva E.N., Sheremetyeva E.V., Fursenko V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.omet-endojournals.ru/jour/article/view/10340">https://www.omet-endojournals.ru/jour/article/view/10340</self-uri><abstract><p>Ожирение – это рецидивирующее полиэтиологическое заболевание. Избыточную массу тела имеют 30–60% женщин репродуктивного возраста, а 25–27% – страдают ожирением. К 2025 г. ожидается, что у 50% женщин нашей планеты будет ожирение. Ожирение у женщин репродуктивного возраста сопровождается высокой частотой ановуляции, синдромом гиперандрогении, нарушениями менструального цикла, патологией эндометрия, бесплодием. При беременности у данной группы женщин выше риск потери на малом сроке, включая беременности в исходе вспомогательных репродуктивных технологий. Увеличение массы тела и развитие ожирения могут привести к снижению фертильности у женщин. Индекс массы тела женщины репродуктивного возраста негативно влияет на течение беременности, а именно: увеличивается риск гестационного диабета, повышения артериального давления, эклампсии, патологического течения родового акта и патологии новорожденного. Ожирение у женщины репродуктивного возраста – самостоятельный фактор риска онкологических заболеваний: рака молочной железы и рака эндометрия, а также приводит к снижению процента выживаемости при раке яичников. Ожирение часто сопровождает синдром поликистозных яичников, который встречается у каждой 10-й пациентки репродуктивного возраста. Сочетание этих заболеваний увеличивает риск таких кардиометаболических состояний, как нарушение толерантности к глюкозе, сахарный диабет 2 типа и дислипидемия. Снижение массы тела у таких пациенток является необходимым компонентом комплексной терапии, направленной на улучшение репродуктивного потенциала.</p></abstract><trans-abstract xml:lang="en"><p>Obesity is a recurring polyetiological disease. Overweight are 30–60% of women of reproductive age, and 25–27% are obese. By 2025, it is expected that 50% of women on our planet will be obese. Obesity in women of reproductive age is accompanied by a high frequency of anovulation, hyperandrogenism, menstrual irregularities, endometrial pathology, infertility. During pregnancy, this group of women has a higher risk of short term loss, including pregnancy in the outcome of assisted reproductive technologies. Weight gain and obesity can lead to decreased fertility in women. The body mass index of a woman of reproductive age negatively affects the course of pregnancy, namely: the risk of gestational diabetes, increased blood pressure, eclampsia, the pathological course of the birth act and the pathology of the newborn increase. Obesity in women of reproductive age is an independent risk factor for cancer: breast cancer and endometrial cancer, and also leads to a decrease in the survival rate for ovarian cancer. Obesity often accompanies polycystic ovary syndrome, which occurs in every 10th patient of reproductive age. The combination of these diseases increases the risk of cardiometabolic conditions such as impaired glucose tolerance, type 2 diabetes and dyslipidemia. Weight loss in these patients is a necessary component of complex therapy aimed at improving reproductive potential.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ожирение</kwd><kwd>избыточная масса тела</kwd><kwd>женщина</kwd><kwd>репродуктивный возраст</kwd><kwd>синдром поликистозных яичников</kwd><kwd>рак эндометрия</kwd><kwd>рак молочной железы</kwd><kwd>бесплодие</kwd><kwd>выкидыш</kwd><kwd>сахарный диабет</kwd><kwd>лираглутид</kwd></kwd-group><kwd-group xml:lang="en"><kwd>obesity</kwd><kwd>overweight</kwd><kwd>woman</kwd><kwd>reproductive age</kwd><kwd>polycystic ovary syndrome</kwd><kwd>endometrial cancer</kwd><kwd>breast cancer</kwd><kwd>infertility</kwd><kwd>miscarriage</kwd><kwd>diabetes mellitus</kwd><kwd>liraglutide</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках Государственного задания «Разработка методик ведения пациентов с эндокринопатиями и бесплодием с учетом постнатальных эффектов на здоровье детей, рожденных в программах вспомогательных репродуктивных технологий» (№ НИОКТР АААА-А18-118051590062-6).</funding-statement><funding-statement xml:lang="en">This work was carried out as part of the State Assignment “Development of methods for the management of patients with endocrinopathies and infertility, taking into account the postnatal effects on the health of children born in assisted reproductive technologies” (R&amp;D AAAA-A18-118051590062-6).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">American Society for Metabolic and Bariatric Surgery. 2015 Year end review. 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