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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ometendo</journal-id><journal-title-group><journal-title xml:lang="ru">Ожирение и метаболизм</journal-title><trans-title-group xml:lang="en"><trans-title>Obesity and metabolism</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2071-8713</issn><issn pub-type="epub">2306-5524</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/omet10052</article-id><article-id custom-type="elpub" pub-id-type="custom">ometendo-10052</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Случай из практики</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Применение терипаратида в лечении тяжелого остеопороза в гериатрической практике: описание клинического случая</article-title><trans-title-group xml:lang="en"><trans-title>Use of teriparatide in treatment of severe osteoporosis in geriatric practice: a clinical case review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7891-6850</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дудинская</surname><given-names>Екатерина Наильевна</given-names></name><name name-style="western" xml:lang="en"><surname>Dudinskaya</surname><given-names>Ekaterina N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>MD, PhD</p></bio><email xlink:type="simple">katharina.gin@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4193-688X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачева</surname><given-names>Ольга Николаевна</given-names></name><name name-style="western" xml:lang="en"><surname>Tkacheva</surname><given-names>Olga N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><bio xml:lang="en"><p>MD, PhD, professor</p></bio><email xlink:type="simple">tkacheva@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2028-3939</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мачехина</surname><given-names>Любовь Викторовна</given-names></name><name name-style="western" xml:lang="en"><surname>Machekhina</surname><given-names>Liubov V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>MD, PhD</p></bio><email xlink:type="simple">mlv66@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1222-3351</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Остапенко</surname><given-names>Валентина Сергеевна</given-names></name><name name-style="western" xml:lang="en"><surname>Ostapenko</surname><given-names>Valentina S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>MD, PhD</p></bio><email xlink:type="simple">ostapenkovalent@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1216-0787</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Браилова</surname><given-names>Наталья Васильевна</given-names></name><name name-style="western" xml:lang="en"><surname>Brailova</surname><given-names>Natalya V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>MD, PhD</p></bio><email xlink:type="simple">n.kokshagina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет им. Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>25</day><month>12</month><year>2019</year></pub-date><volume>16</volume><issue>4</issue><fpage>80</fpage><lpage>89</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дудинская Е.Н., Ткачева О.Н., Мачехина Л.В., Остапенко В.С., Браилова Н.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Дудинская Е.Н., Ткачева О.Н., Мачехина Л.В., Остапенко В.С., Браилова Н.В.</copyright-holder><copyright-holder xml:lang="en">Dudinskaya E.N., Tkacheva O.N., Machekhina L.V., Ostapenko V.S., Brailova N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.omet-endojournals.ru/jour/article/view/10052">https://www.omet-endojournals.ru/jour/article/view/10052</self-uri><abstract><p>Для людей пожилого и старческого возраста характерна высокая распространенность остеопороза, который, в свою очередь, повышает риск переломов, в том числе и повторных. Переломы при остеопорозе являются крайне неблагоприятным осложнением заболевания, приводящим к катастрофическим последствиям в пожилом возрасте. Распространенность остеопоротических переломов прогрессивно возрастает с увеличением возраста. В настоящий момент кумулятивная частота переломов бедра у женщин старше 80 лет составляет около 30%. Доля переломов тел позвонков у женщин старше 80 лет составляет до 40% всех вертебральных остеопоротических переломов. Несмотря на огромные успехи, достигнутые в диагностике и лечении остеопороза, само заболевание и связанные с ним переломы остаются серьезной медицинской экономической и социальной проблемой.</p><p>Профилактика повторных переломов у гериатрических пациентов представляет собой систему профилактических, реабилитационных и лечебных мероприятий, направленных на снижение риска падений, выбор эффективной терапии, снижение риска повторных переломов.</p><p>Серьезной проблемой в лечении остеопороза у лиц старшего поколения становится неэффективность проводимой антирезорбтивной терапии вследствие возрастного снижения костеобразования. Нередки случаи продолжающегося снижения плотности кости, возникновения повторных переломов на фоне проводимой терапии остеопороза. Часто терапией выбора в данном случае становится костно-анаболическая терапия терипаратидом, что позволяет достигнуть хороших результатов в накоплении минеральной плотности кости. В данной статье нами будет рассмотрен клинический случай пациентки старческого возраста с тяжелым остеопорозом, препаратом выбора в лечении которой стал терипаратид.</p></abstract><trans-abstract xml:lang="en"><p>Elderly and senile people are characterized by a high prevalence of osteoporosis, which, in turn, increases the risk of fractures, including the repeated ones. Fractures in osteoporosis are an extremely unfavorable complication of the disease, leading to catastrophic consequences in old age. The prevalence of osteoporotic fractures progressively increases with age. At present, the cumulative frequency of hip fractures in women over 80 is about 30%. The proportion of vertebral fractures in women older than 80 years is up to 40% of all vertebral osteoporotic fractures. Despite the tremendous successes achieved in the diagnosis and treatment of osteoporosis, the disease itself and related fractures remain a serious medical, economic and social problem. Prevention of recurrent fractures in geriatric patients is a system of preventive, rehabilitative and therapeutic measures aimed at reducing the risk of falls, choosing an effective therapy, and reducing the risk of recurring fractures. A serious problem in the treatment of osteoporosis in older people is the inefficiency of the antiresorptive therapy due to an age-related decrease in bone formation. There are frequent cases of a continuing decrease in bone density, the occurrence of repeated fractures during ongoing therapy of osteoporosis. Often the therapy of choice in this case is bone-anabolic therapy with teriparatide, which allows one to achieve good results in the accumulation of bone mineral density. In this article, we will present the clinical case of an elderly patient with severe osteoporosis, in which teriparatide became the drug of choice.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пожилые</kwd><kwd>клинический случай</kwd><kwd>старческая астения</kwd><kwd>остеопороз</kwd><kwd>терипаратид</kwd><kwd>переломы</kwd><kwd>МПК</kwd><kwd>денситометрия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>elderly</kwd><kwd>clinical case</kwd><kwd>frailty</kwd><kwd>osteoporosis</kwd><kwd>teriparatide</kwd><kwd>fractures</kwd><kwd>DXA</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cooper C, Campion G, Melton LJ 3rd. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 1992;2(6):285-289. DOI:10.1007/BF01623184</mixed-citation><mixed-citation xml:lang="en">Cooper C, Campion G, Melton LJ 3rd. Hip fractures in the elderly: a world-wide projection. 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